Peri-operative antibiotics have a significant role to play in the prevention of hospital acquired infections. Poor prescribing practice can lead to the emergence of resistant organisms and antibiotic associated infections. An audit was undertaken in which the first audit cycle identified current antibiotic prescribing practice for 139 patients. 5 patients had received antibiotics when not indicated. Following this, evidence based guidelines were issued to improve and standardise prescribing throughout the department. The second audit cycle included 128 patients and identified only 1 patient receiving inappropriate antibiotics and 1 not receiving antibiotics when they were indicated. No adverse events were identified.