An Update on the Pathogenesis of Chronic Rhinosinusitis

Rate this item
(0 votes)


Chronic rhinosinusitis (CRS) is a commonly reported disorder characterized by persistent inflammation of the mucosa of the nose and paranasal sinuses. Although the pathogenesis remains poorly understood, CRS is thought to be disease arising from the interaction between environmental pathogens and host innate immunity. A number of factors have been implicated as etiologic agents such as bacterial biofilms, superantigens and fungi. However, studies aiming to eradicate these environmental agents have remained inconclusive causing researchers to hypothesize that the pathogenesis of CRS may instead be due to a variety of genetic and epigenetic changes within the host response in select patients. This review will highlight current perspectives on various environmental contributors with an overview of the sinonasal innate immune system and its role in the pathogenesis of CRS.

Additional Info

Read 4401 times Last modified on Tuesday, 10 December 2013 12:21

Leave a comment

Make sure you enter the (*) required information where indicated. HTML code is not allowed.


Member Login

          Forgot login? | Register

BBC News Feed

Get in touch

+44 207 637 3544

This email address is being protected from spambots. You need JavaScript enabled to view it.

The Otorhinolaryngologist,
73 Newman Street, London
W1T 3EJ, 


Rila Publications Ltd Ethics Policy