Background: Herpes simplex virus type 1 infections of the head and neck area are common, with a wide variation in presenting symptoms. Isolated involvement of the larynx is rare.
Methods and Results: We describe the case of a 68 year old man who presented with a necrotising mass lesion of the larynx due to herpes simplex virus, confirmed by histopathology and immunohistochemistry studies of a laryngeal biopsy. Clinically and radiologically, this lesion mimicked a neoplasm, leading to diagnostic difficulty.
Conclusion: Laryngeal herpetic infections may present with mass lesions which may simulate a malignant neoplasm.